Free triiodothyronine concentrations as measured by two one-step radioimmunoassays in nonthyroidal illness.
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چکیده
منابع مشابه
Clinical value of immunoradiometric assay of thyrotropin for patients with nonthyroidal illness and taking various drugs.
Using a two-site immunoradiometric assay, we measured concentrations of thyrotropin (TSH) in serum of 134 clinically euthyroid subjects, 93 patients with nonthyroidal illness, and 80 patients who were being treated with various drugs. Abnormal concentrations of TSH, free thyroxin, and free triiodothyronine, respectively, were recorded in serum of three (3.2%), 19 (20.4%), and 37 (39.8%) of the ...
متن کاملDirect and indirect techniques for free thyroxin compared in patients with nonthyroidal illness. III. Analysis of interference variables by stepwise regression.
We applied stepwise regression for multivariate analysis of data for free thyroxin (FT4) in serum and for other laboratory tests of thyroid function in patients with nonthyroidal illness. Using the maximum R2 improvement and backward elimination methods to test five variables [prealbumin, albumin, T4-binding globulin (TBG), free fatty acids (FFA), and FFA/albumin molar ratio], we found that the...
متن کاملDirect and indirect techniques for free thyroxin compared in patients with nonthyroidal illness. II. Effect of prealbumin, albumin, and thyroxin-binding globulin.
We studied the correlation of thyroxin (T4)-binding proteins with the apparent free T4 (FT4) in 101 patients with nonthyroidal illness (NTI). Most patients (95%) were seriously ill at the time of blood collection. Concentrations of T4-binding prealbumin (transthyretin), albumin, and T4-binding globulin (TBG) often were low in the sera of these patients. Albumin was the most frequently subnormal...
متن کاملDiscrepancies between serum free triiodothyronine and free thyroxin as measured by equilibrium dialysis and analog radioimmunoassay in nonthyroidal illnesses.
We determined free triiodothyronine (FT3) and free thyroxin (FT4) in serum of patients with various nonthyroidal illnesses (NTI), by both commercial analog-type radioimmunoassays (A) and new equilibrium dialysis procedures (D). The mean FT3 was significantly lower in NTI by both techniques, but the decreases were of different magnitudes. The FT3(D):FT3(A) ratio was 1.96, vs 1.11 for healthy con...
متن کاملImproved dialysis method for free thyroxin in serum compared with five commercial radioimmunoassays in nonthyroidal illness and subjects with abnormal concentrations of thyroxin-binding globulin.
We describe a method for free thyroxin (FT4) in serum, based on radioimmunoassay of T4 in serum dialysate, FT4(D). The method is analytically accurate, sensitive, reproducible, and suitable for routine use in the clinical laboratory. We compared results by this method with those obtained with five commercial FT4 assays (Amerlex, GammaCoat, ImmoPhase, LiquiSol, Spiria) and the free T4 index (FT4...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 37 1 شماره
صفحات -
تاریخ انتشار 1991